Aquatic disease produces an account more complex, baconian have:

(1) the nutrition of feed is not comprehensive. Aquatic of the lack in feed grows an indispensible vitamin, mineral etc, cause breed an object hidebound, disease-resistant ability is abate;

(2) the water quality that basically causes because of incomplete bait, excrement and urine is exasperate, offer for pathogen create a place;

(3) multiply and invade aquatic organism what a large number of conditions send ill pathogen;

(4) the operation is not meticulous, cause aquatic loss.

So, because interaction of feed, environment, cause of disease, host is caused,aquatic disease is, cut off among them any chain link, it is one of ways of disease of aquatic of effective prophylaxis and treatment. Of article discussion is use formalin (Formalin) undertake alexipharmic to water quality, restrain and exterminate pathogen, reduce cause of disease microbial the biomass with helminth, block breaks pathogen this one important chain link, in order to achieve the goal of disease of control aquatic animal. On June 18, 1998, FDA (American food and medicaments management board) already approved brigadier formalin to be used on egg of all fish having fin certain fungus and certain body expresses all fish having fin the control of protozoan and odd breed fluke.

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Formalin is the aqueous solution of 40% formaldehyde, have intense excitant taste, it is protein coagulating agent, can restrain virus, bacterium, fungus, helminth and plankton, in aquatic product vaccine the middling that make adds the formalin antagonism of 1% to undertake destroying living formerly. Change in terrapin factory formalin is used to be able to have peculiar effect to disease of prevention and cure in breeding. According to the experiment, deadly to the lowest of turtle chroma is formalin 10-6 of 200 × 10-6~400 × , bear on average be restricted (TLM) 10-6 of 24 hours of 1130 × , 10-6 of 48 hours of 580.3 × , 10-6 of 96 hours of 400 × , safe chroma 45.9 × 10-6, recommend use chroma: Dipping 50 × 10-6 (1~2 hour) , douse 20 × 10-6 (Yang Xianle, 1995) . The attenuant solution of formalin can be when low density in aquatic animals box use, basically use at treating the pathogen outside the body of most fish, mix to the skin especially disease of mucus of the fluke of branchial ministry, skin and dot of briny fish sperm are ill, curative effect quite beautiful.

Formalin can use up the oxygen in water and the branchial organization that harm fish, can make piscine mucus, cuticular protein caky, accordingly, douse chroma is exorbitant, to branchial, body of the fish the watch all has a harm. Its drug effect and the temperature when using, environment is concerned, water is warm it is when 26 ℃ of 23 ～ , to eel 48 hours of the biggest safe chroma are 56 × 10-6, the douse when be being used actually commonly 30 × 10-6 is hurtless, but water is warm when 28 ℃ above, to Chi Shuizhong plankton has exterminate action, cause water quality addle easily. In treating a process, whether do the dissolve oxygen capacity that needs to increase water adequately and the branchial ministry that notice to watch ill fish produce unusual situation, so that appropriate is handled, once produce any undesirable unusual reaction, must stop treatment, go to ill fish shift clean and water dissolve oxygen goes in abundant water quality environment. Formalin also can cause intense harm without vertebral biology to seawater. Change in the factory in breeding, the nitrification in system of filter of same meeting opposite can produce formalin bad influence, it is after disuse, need instant complement to add nitrify bacterium.
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